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In some embodiments, the otic composition or formulation comprises less than 7% by weight of C1-C4 alcohols or C1-C4 glycols

The role of beta cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs

Research has described effects on fibroblast activity, including reported up-regulation of collagen, elastin, glycosaminoglycan, and decorin production in cellular models

Arg323 is critical, forming two salt bridges per subunit with Asp332 and Glu333, and also stabilizing the active enzyme conformation, being in a loop just after the structural elements of the active site (Ortz et al