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Lung cancer was the second-most diagnosed cancer for both men and women in the United States in 2024, behind breast cancer in women and prostate cancer for men, according to the American Cancer Society

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A better understanding of the physiopathogenic mechanisms involved in CR could lead to better treatment for these patients.3,4 OBJECTIVES In the present paper we reviewed the evidence pointing towards the cigarette smoke effects on the respiratory epithelium as well as its role on the pathophysiology of chronic rhinosinusitis