Abbreviations RA: Rheumatoid arthritis TCM: Traditional Chinese medicine BR: Bilirubin RM: Red blood cell membranes Cel: Celastrol ROS: Reactive oxygen species RES: Reticuloendothelial system HA: Hyaluronic acid PBS: Phosphate Buffered Saline MD: Molecular dynamics RMSD: Root mean square deviation SASA: Solvent-accessible surface area 1 H-NMR: Hydrogen nuclear magnetic resonance spectroscopy DMSO-d6: Dimethyl sulfoxide-d6 D 2 O: Deuterium oxide Cou6: Coumarin 6 DIR: 1,1-Dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodine DCFH-DA: 2,7-dichlorofluorescein diacetate DAF-FM DA: 4-amino-5-methylamino-2,7-difluorofluorescein diacetate NO: Nitric oxide WB: Western blotting PCA: Principal component analysis DEGs: Differentially expressed genes KEGG: Kyoto Encyclopedia of Genes and Genomes micro-CT: Micro-computed tomography H&E: Hematoxylin and eosin SO-FG: Senna O-Fixed Green TRAP staining: Tartaric acid staining PBS: Phosphate-buffered saline ALP staining: Alkaline phosphatase staining ALT: Aminotransferase AST: Aspartate aminotransferase CCK8: Cell Counting Kit-8 UV-vis: Ultraviolet-Visible Spectrophotometryp FT-IR: Fourier Transform Infrared Spectroscopy LPS: Lipopolysaccharide SDS-PAGE: Sodium dodecyl sulfate-polyacrylamide gel electrophoresis References Smolen JS, Aletaha D, Barton A, Burmester GR, Emery P, Firestein GS, et al

AEDG) used in controlled in-vitro research to explore telomere biology pathways, cellular senescence markers, and circadian-related peptide signalling under non-clinical conditions
Gastrointestinal Protection Research : Research evaluates protective effects on the digestive tract, particularly under conditions of stress or chemical irritation
It is more common for results to be low, although pituitary tumors (sometimes leading to gigantism or acromegaly) can produce unusual results