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Long-term effects of Abeta42 immunisation in Alzheimers disease: follow-up of a randomised, placebo-controlled phase I trial

Glutamate can be further converted to -ketoglutarate (-KG) through oxidative deamination by glutamate dehydrogenase (GLUD1) or transamination by glutamate-linked transaminase as an anaplerotic substrate in the TCA cycle for energy production (Figure 1)

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Although reduced levels of ferroptosis inhibitors (e.g