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Additional information Edited by G Melino Supplemental Information accompanies the paper on the Cell Death Discovery website ( Supplementary information Rights and permissions This work is licensed under a Creative Commons Attribution 4.0 International License

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Impact of Toxins on P450 Enzymes and Methylation Exposure to toxins, drugs, and alcohol can impair the activity of P450 enzymes, leading to a decrease in SAMe production and impaired methylation

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