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In the secondary analysis where researchers stratified timing of e-cigarette initiation, women who initiated e-cigarette use before pregnancy had a higher smoking abstinence rate compared with nicotine replacement therapy users (53.1% vs

Based on evidence of generally low quality, a Cochrane review of acute postoperative pain reported that nicotine formulated as a nasal spray or transdermal patch could reduce pain scores at 24 h postoperatively compared with placebo, but the effects were relatively small (0.88 points on a 010 pain scale) [20]

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