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Notably, baseline levels of butyrate and butyrate-producing species positively correlate with clinical response to antiTNF- therapy in humans (201, 202), highlighting butyrate's role in restoring epithelial barrier function, immune regulation, and biologic therapy efficacy

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(5) Additionally, Pinealon has been associated with increased levels of irisin, a peptide that has been implicated in neural differentiation, proliferation, and energy expenditure within the brain

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