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Abstract Introduction: Methotrexate (MTX), a folic acid antagonist and nucleotide synthesis inhibitor, is a cornerstone drug used against acute lymphoblastic leukemia (ALL), but its mechanism of action and resistance continues to be unraveled even after decades of clinical use

TAG is hydrolyzed sequentially to form diacylglycerol (DAG), then monoacylglycerol (MAG), with the liberation of a FA at each step

Patient education is key

Activity must be appropriately loaded, not either absent or excessive: Complete rest prevents the mechanical stimulus that signals the tendon to rebuild with the appropriate architecture