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It exhibited its immunomodulatory effect by decreasing the expression levels of MyD88, TLR4, TRAF6, and p65 genes and increasing the expression levels of I-B gene, MyD88, TLR4, TRAF6, phosphorylation p65, and phosphorylation I-B proteins in TLR4- NF-B signaling pathway

~3-week-old Mmut p.L690Ins/p.L690Ins , Mmut p.L690Ins/WT , and Mmut WT/WT mice were removed from breeder cages and fasted for 4 hours before collecting blood in green-top collection tubes via retroorbital bleeding

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