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Hyperglycemia also stimulates the transcription nuclear factor (NF-B), which in turn causes overexpression of specific gene sequences that control the regulation of numerous inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-), and cyclooxygenase-2 (COX-2) (Figure 1) for in silico analysis, and nuclear factor kappa B (NF-B), tumor necrosis factor-alpha (TNF-), and cyclooxygenase-2 (COX-2) for in vivo investigations

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Glutathione is considered the most important antioxidant because it is the only one capable of working with enzymes