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Following administration in preclinical models: Intravenous administration provides immediate systemic availability Intramuscular injection demonstrates absorption with peak levels within 1-2 hours Individual peptide components show variable tissue distribution patterns Blood-brain barrier penetration demonstrated for certain neuropeptide fractions Distribution studies indicate that some peptide components can cross the blood-brain barrier, though the extent varies by molecular weight and specific peptide characteristics

BPC 157 may accordingly antagonize both COX 1- and COX 2-NSAIDs effect on lower esophageal sphincter and pyloric sphincter

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