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Major drug Interactions: Decongestants Local anesthetics w/ sympathomimetics Antihypertensives CNS depressants Drugs metabolized by P450-2D6 Concomitant use of MAOI's can cause potentially fatal hyperpyretic crisis & seizures History: The therapeutic & commercial success of phenothiazine antipsychotics initiated a large scale search for more effective antipsychotics during the early 1950's