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Cancer Risk: IGF-1 LR3 is one of the riskiest compounds discussed in regenerative research due to its potent mitogenic (cell division) properties

This KRT17 + population showed the highest similarity to the SOX9 + cell population, and more specifically the SOX9 + proliferative and SOX9 + LGR5 + populations as present in vivo [1]

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Overall, this review should be viewed as hypothesis-generating, mapping candidate pathways and highlighting priorities for well-designed intervention studies to test these mechanisms and strengthen causal inference