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In ME/CFS and Long COVID, researchers have identified a 'mitochondrial-peroxisomal vicious cycle.' As mitochondria attempt to generate adenosine triphosphate (ATP) for energy, damaged electron transport chains 'leak' electrons, creating highly reactive superoxide radicals

Together, these agents collectively influence serotonergic, dopaminergic, and noradrenergic transmission, brain-derived neurotrophic factormediated plasticity, inflammatory cascades, oxidative stress, and mitochondrial bioenergetics, pathways that are increasingly recognized as interdependent in the pathophysiology of depression (23)

If a medication is changing the color of your urine, but it isnt causing any other symptoms, the change is often harmless