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On the other hand, SESN1 functions as a physiological leucine sensor for mammalian target of rapamycin complex 1 (mTORC1), precisely regulating mTORC1 activity in response to intracellular leucine levels and dietary changes with mTORC1 being a master controller of cell growth, protein synthesis, and lipid metabolism [21]

HO-1, an Nrf2-regulated antioxidant factor, catalyzes heme degradation and releases anti-inflammatory mediators, thereby exerting anti-inflammatory effects 15

9(7): p

The thing that really saved me, Huberman tells Peter Attia, was this therapy thing I was like, Oh, shit I do have to choke back a little bit here