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Novartis Pluvicto established radioligand therapy as a commercial reality (2022+): Lutetium-177 PSMA-617 (Pluvicto) for metastatic castration-resistant prostate cancer achieved rapid adoption post-2022 launch, validating the peptide receptor radionuclide therapy platform and creating a template for multiple follow-on radioligand therapy programmes

1 Introduction Degenerative orthopaedic diseases, such as osteoporosis (OP), osteoarthritis (OA), and lumbar disc herniation (LDH), gravely undermine patients quality of life