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Within hepatocytes, the metformin-mediated activation of AMPK results in suppression of both glycogenolysis and gluconeogenesis, effects that limit glucose output by the liver

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5.1.1.2 Oxidative stress markers In migraine patients, levels of malondialdehyde (MDA) are significantly elevated, especially in cases of migraine with aura, reflecting increased lipid peroxidation and oxidative stress damage (Tuncel et al., 2008)