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Increased levels of ROS/RNS, generated from both endogenous (mitochondria, NADPH oxidases) and/or exogenous sources (radiation, certain drugs, foods, cigarette smoking, pollution) result in a harmful condition termed oxidative stress (bad stress)

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In terms of target selection and host toxicity, the homology with eukaryotic organisms can interfere with host function, and drug penetration efficiency is insufficient

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