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The difference between a peptide that remains highly functional for weeks and one that loses activity within days is often not the peptide itselfit is the way it is prepared, stored, and handled

Individual response patterns also influence peptide selection

It is a substrate for -ketoglutarate dehydrogenase (OGDH) in oxidative reactions generating succinyl-CoA and isocitrate dehydrogenase 1 (IDH1) or isocitrate dehydrogenase 2 (IDH2), which catalyze the reductive carboxylation reaction converting -KG to isocitrate

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