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[63] In May 2021, Snyder revealed that he had written an Alexander the Great film that was intended to function as a conclusion to the 300 trilogy, adapting the Rise of Alexander segment of Xerxes , but it evolved into having a greater focus on a love story between Alexander and Hephaestion, leading Snyder to think it could not function as a third 300 film, but rather a stand-alone entry in the same fictional universe

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Biologic Therapy for Severe Asthma (Step 5) Per CHEST 2026 Biologic Guidelines and ACCP 2026, biologic selection is based on phenotype: Allergic (T2-high, high IgE): Omalizumab (anti-IgE, Xolair) approved 6 years

For context, there are about 333 million people in the U.S