GCL is in part regulated by GSH feedback inhibition, thus if GSH is depleted due to oxidative stress, inflammation, or exposure to xenobiotics, de novo synthesis of GSH is upregulated, as is cysteine synthesis
Prez-Garca S, Carrin M, Gutirrez-Caas I, et al
Conversely, in conditions of ER stress, Ca 2+ is released in excess and accumulates in the mitochondria, causing the mPTP opening and the depolarization of the inner membrane 50
43 amino acids Sequence: SDKPDMAEIEKFDKSKLKKTETQEKNTLPTKETIEQEKQAGES Formula / M.W.: C 212 H 350 N 56 O 78 S, ~4963.44 g/mol CAS: 77591-33-4 Disclaimer This product is intended for laboratory research use only