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Besides, caffeic acid and chlorogenic acid (caffeoylquinic acids) are two other classical phenolic acids widely found in natural plants, both of which are the most vital active substances in coffee [168]

doi: 10.1002/mds.26351

Concurrently, this ROS burst activates the NF-B pathway, perpetuating pro-inflammatory cytokine secretion (TNF-, IL-1, IL-6) and establishing a vicious cycle of chronic inflammation

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