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What ties all of these symptoms together is inflammation

3 PART 2

This delivery system successfully traversed the blood-brain barrier (BBB), improved the transport of DMC to dopaminergic neurons and microglia in the substantia nigra pars compacta of Parkinsons disease (PD) mice, and intervened in PD (270)

Subsequent studies from other groups have confirmed our original findings.65 Pleiotropic effects involving distinctive receptors, including VEGFR2 and growth hormone receptors, distinctive pathways, including VEGFR2-AKT-eNOS, ERK , FAK-paxillin, FoxO3a, p-AKT, p-mTOR and p-GSK-3, and distinctive loops, including stimulation of the egr-1 gene and its corepressor gene naB2, and counteraction of increases in pro-inflammatory and procachectic cytokines, likely minimize the inherent lack of full understanding of the mechanisms that may be involved