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Appreciating the potential for an internal hydrogen bond due to the amino group in the -position of C -terminal 2,4-diaminobutyric acid and the potentially confounding behavior of 1p / 1n , we extended the amino group further from the -carbon in 2n / 2p

We also acknowledge the help and support of the Discovery and Pipeline Genetics, and Translational Medicine and Genetics departments at GSK for their contributions to this study

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