Still, copper peptides offer enough promise to remain a popular and closely studied ingredient in modern skincare
maintains circulation to the brain to promote memory and mood, especially in the elderly.(31) Guarana - South American Berry that is one of the best natural sources of caffeine, traditionally used to boost mind energy and physical endurance.(32) Huperzine-A - synthetic alkaloid from Chinese club Moss, used to sustain acetylcholine levels and shown to help with memory and degenerative brain concerns.(33) Kanna (Sceletium tortuosum) - South African herb shown in research to help with mental alertness in seniors with brain degeneration and cognitive deficits.(34) Kava Kava - psychoactive root herb used in traditional South Pacific ceremonies
Balakrishnan B, Mohanty M, Pr U, Athipettah J (2005) Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin
The total human evidence base, as of this writing, consists of the following: 1) a Phase I safety trial of 42 healthy volunteers that was registered in 2015, canceled in 2016, and never published, 2) a retrospective case series of 12 patients with knee pain, no control group, and no validated outcome measure, and 3) a 2025 pilot safety study involving two healthy adults who received intravenous infusions at a single private clinic in Florida