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PMID: 19652057

It is endogenously distributed across both central and peripheral tissues, including the hypothalamus, pituitary gland, and limbic system, making it a broadly studied subject in neuroendocrine and sleep biology research

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Compounding pharmacies prepare these formulations under USP Chapter 797 guidelines for sterile compounding, and the beyond-use dates they assign are based on a combination of USP default dating, any proprietary stability testing they have conducted, and the specific formulation used