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Specifically, these fucoidans have been found to mitigate the reduction in protein levels of the antioxidant enzyme GPX4, offering partial protection against erastin-induced oxidative stress and ferroptosis in ARPE-19 cells ( 3.2.5 Vitamin A metabolites Vitamin A, also known as retinol, is a fat-soluble vitamin that serves as a precursor for various bioactive substances, including retinaldehyde (retinal) and different forms of retinoic acid ( 3.3 Pharmacodynamic elements from traditional Chinese medicine 3.3.1 Puerarin Puerarin (C21H20O9), a natural isoflavone derived from Pueraria lobata and utilized in traditional Chinese herbal medicine, has been proven to possess preventive properties against iron overload (Song et al., 2020)

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Seaks and Wilcock, 2020), or else through the compromised blood brain barrier (Kivimki and Walker, 2024), through leaky gut (Khler et al., 2016) and also the lung (Chen et al., 2023)