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MATERIALS AND METHODS Animals Male Albino Wistar (350-400 g) rats, were used in all of the experiments (10 rats at least per each experimental group and interval randomly assigned) approved by the Local Ethic Committee and assessed by observers unaware of the given treatment

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Standard 10 mg vial titration protocol Based on clinical trial dose escalation schedules and adjusted for the 10 mg vial format, here is the most commonly referenced protocol

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