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However, direct supplementation with glycine has been shown to affect gut microbiome, immune response gene expression, and serum concentrations of various amino acids ( Betaine could benefit low protein diets by supplying animals with a form of glycine that is released slowly after the betaine molecule has already contributed its methyl group so that the negative effects of glycine can be avoided

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10.1016/S0891-5849(96)00338-3

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