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1 Introduction Bone defects are commonly encountered in clinical practice and can arise from various causes, including trauma (e.g., fractures), age-related bone loss (e.g., osteoporosis), infections (e.g., osteomyelitis and periodontitis), cancer (e.g., surgical resection), genetic diseases (e.g., inherited bone marrow failure syndrome), and congenital defects (e.g., cleft palate)

[DOI] [PubMed] [Google Scholar] Ahmadi Y, Ghorbanihaghjo A, Argani H, 2017

Mice that lack the expression of aSYN exhibited dysfunction in the ability of hippocampal synapses to respond to prolonged stimulation, which is expected to cause depletion of the docked and reserve pool of synaptic vesicles

Prog Neuropsychopharmacol Biol Psychiatry 2015;57:69-75