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Neurobiol Dis 37:1325 Liebner S, Czupalla CJ, Wolburg H (2011) Current concepts of blood-brain barrier development

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INTRODUCTION -L-glutamyl-L-cysteinyl-glycine chiefly known as glutathione (GSH) is required for several cell processes interconnected with alterations in the maintenance and regulation of the thiol-redox status, due to its capability to exist in different redox specie ( S -glutathionylation is an important on/off mechanism for dynamic post-translational regulation of a variety of regulatory, structural and metabolic proteins involved in signaling and metabolic pathway in cell systems ( S -nitrosylation, and DNA strand breaks in neuronal cells