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Another randomized controlled trial observed the upregulation of vitamin D receptor ( VDR ), glutathione S-transferase A3 ( GSTA3 ) and interleukin 21 receptor ( IL-21R ), as well as the downregulation of prostaglandin-endoperoxide synthase 2 ( PTGS2 ), advanced glycosylation end-product specific receptor ( AGER ) and retinoid X receptor beta ( RXRB ) in women receiving vitamin D supplementation compared to placebo (80)

After adjusting for background factors using inverse probability of treatment weighting, the difference remained statistically significant, suggesting a robust association between long-term dietary adherence and improved prognosis [155]

doi: 10.1016/j.freeradbiomed.2019.05.035 286 ValdsA.Ortega MorenoL.Rojo RelloS.OrduaA.BernardoD.CifuentesA

Nat Neurosci 2003