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The intracellular redox state exists in a dynamic equilibrium [2], orchestrated by controlled reactive oxygen species (ROS) production and elimination [3, 4]

On the one hand, ROS induce oxidative damage to cysteine residues within the MutS complex (MSH2-MSH6 heterodimer), specifically impairing its ATPase-dependent DNA mismatch recognition capacity

doi: 10.1056/NEJMoa2012410 CrossRef Google Scholar View reference in article 14 CantiniFNiccoliLMatarreseDNicastriEStobbionePGolettiD