glutathione detox reaction IV Detox: Is It Right? Glutathione-Mediated Conjugation of Anticancer Drugs

15 ROS include radical compounds, such as superoxide, hydroxyl radicals, and lipid hydroperoxides, and reactive nonradical compounds, such as singlet oxygen, hydrogen peroxide (H 2 O 2 ), hypochlorous acid, chloramines, and ozone

& Kapsenberg, M

TABLE 2Active metabolites developed as drugsMetabolite drugs Parent drugsAcetaminophen PhenacetinCetirizine HydroxyzineDesimipramine ImipramineDesloratadine LoratadineDigoxin -methyldigoxinFexofenadine Terfenadine (withdrawn due to cardiotoxicity)Mesoridazone ThioridazoneMorphine CodeineNortriptyline AmitriptylineOxazepam DiazepamPhenobarabital PrimidoneN-Acetylprocainamide Procainamide (A

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