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Current markers (e.g., GPX4, 4-HNE, and serum iron) lack specificity for ferroptosis-driven RF, as they are also altered in other kidney diseases or metabolic disorders
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As with CYP2E1, there are substantial inter-ethnic differences in CYP2D6 across populations, ranging from complete loss of function or reduction in functional activity (2570% of the population, dependent on ethnic origin and geographical location) to extensive, ultra-rapid metabolisers (1.59.3% of the population) (see Table 3 in the supplementary data for a summary of the evidence) [17, 38]
Nonsegmental vitiligo is the most common type of vitiligo where depigmented patches appear on both sides of the body
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