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Meta analyses did not find any significant effects with melatonin on insomnia disorder (75) , secondary sleep disorders associated with medical, neurological, or substance abuse disorders (5) , or on sleep quality in menopausal women (71) , but supplementation improved subjective sleep quality in patients with traumatic brain injury (44) and Parkinsons disease (76) , and cognitive outcomes in patients with Alzheimers disease (72)

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Even though it is considered to be human tumor with the most prominent immunogenic response, malignant melanoma represents one of the most insidious cancer for its ability to rapidly disseminate and induce metastasis [3]