methionine and glutathione Vitamin B12 is the essential cofactor that lets the Folate Cycle hand a methyl group to homocysteine (via synthase), enabling methionine → SAMe production; SAMe is the cell's universal methyl donor methionine glutathione synthesis Metabolism -

Indeed, GSTP1 expression can predict pathological response to chemotherapeutic treatments with 5-fluorouracil/epirubicin/cyclophosphamide in ER-negative tumors but not in ER-positive tumors

R How To Improve Conjugation The goal is to ensure every conjugation pathway has its required cofactors, the relevant enzymes are properly induced, and the excretion routes (bile, urine, stool) are functioning

Glutathione This naturally occurring antioxidant supports liver detoxification and helps lighten hyperpigmentation

Mitochondria contain multiple copies of their own genome, mitochondrial DNA (mtDNA), which encodes for 13 polypeptides of the OXPHOS and respiratory chain, as well as two ribosomal RNAs and 22 transfer RNAs necessary for translation of polypeptides inside mitochondria