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Endoplasmic reticulum stress-activated transcription factor ATF6 requires the disulfide isomerase PDIA5 to modulate chemoresistance

Keep in mind that evidence is preliminary and largely based on animal studies or small human trials

Loss of SLC25A39 inhibits the proliferation and migration of LUAD cells To further elucidate the role of SLC25A39 in LUAD cells, we generated stable SLC25A39 knockout cell lines (koSLC25A39) by transducing Cas9-expressing A549 and H1299 cells with a CRISPR/Cas9 vector targeting SLC25A39