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As of 2019, China Tobacco had expanded its global reach to 20 countries, operating through 34 off-shore facilities, which include sales offices, manufacturing plants, and specialized tobacco procurement companies, according to Fang

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This is consistent with the incentive-sensitization theory of addiction 4, 5 , which proposes that neutral stimuli can promote drug-seeking behaviour through association with drug effects, and that this is mediated through sensitization of particular brain systems, principally the ventral striatum

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