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Alternative synthetic approaches have been described by Zhang and associates, wherein p-benzoquinone was reacted with concentrated sulfuric acid and acetoacetate (0.15:3:1 molar ratio) at 45 C for 3 h, producing peracetylated 1,2,4-benzenetriol

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Clouded by the fact that patients may have signs of more than one rosacea subtype at the same time and signs and symptoms vary from patient to patient, dermatologists have to consider all groups --- visually because there is no specific test for rosacea to guide them so it would not be unusual for the doctor to order tests to rule out other conditions that look similar to rosacea

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