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J Environ Sci Heal A

[DOI] [PMC free article] [PubMed] [Google Scholar] Ridker PM, Danielson E, Fonseca FAH, Genest J, Gotto AM, Kastelein JJP, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ, 2008

In parallel, dihydroorotate dehydrogenase (DHODH) and sulfide:quinone oxidoreductase (SQOR) were shown to generate ubiquinol (CoQ 10 H 2 , reduced) within mitochondria using dihydroorotate and selenide, respectively 23,24

In conclusion, our findings uncovered a novel physiological role for GH, which is to signal caloric deficiency to the brain, triggering important adaptive responses to conserve energy via activation of AgRP neurons