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797 Even neonatal rat ventricular muscle cells with low sensitivity to GPX4 inhibition underwent ferroptosis in the presence of cysteine deprivation, suggesting that inhibition of GPX4 promotes ferroptosis of cardiomyocytes under metabolic stress, such as cysteine deprivation

The exploration of synthetic neurotrophin mimetics or peptidomimetics, which can overcome the pharmacokinetic limitations of native proteins, represents a promising direction for therapeutic development (Sefiani et al., 2026

Furthermore, genetic deletion of specific GABA A receptor subunits have indicated spatiotemporal-specific functions in regulating proliferation, migration and maturation processes that constitute adult hippocampal neurogenesis [122, 124]

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