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One study found that the levels of THTR-1, transketolase, and TPP mitochondrial transporters were increased in samples of human breast cancer tissue compared to normal tissue, suggesting an adaptation in thiamin homeostasis in support of cancer metabolism (95)

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Peak plasma concentration (Cmax) for SubQ administration typically occurs 34 hours post-injection, with a lower maximum level than IM but sustained elevation lasting 68 hours total