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The more efficient conjugation of the QIs to GSH may have reduced covalent modification of cellular macromolecules, like ER proteins Grp78/Bip (Xu et al., 2015), microsomal GST (Weis et al., 1992), and PDI ( Although reactive QI formation has been associated with AQ-induced (cyto)toxicity in vitro ( in vivo (Wink et al., 2014, 2017)
The autoantibodies in this process against the TSH receptor continuously stimulate the thyroid gland toward hyperplasia and production of increased amounts of hormones (Antonelli et al
This is especially important in regions like MENA and South Africa, where fluctuating climates, urban pollution, and lifestyle factors can impact immunity