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Cagrilintide monotherapy remains investigational, and the CagriSema combination has been submitted for regulatory review but remained unapproved as of this writing

The recommended starting point for finding UK trials is: NIHR Be Part of Research (bepartofresearch.nihr.ac.uk) the UK's public-facing portal for finding and joining clinical research studies ClinicalTrials.gov and the EU Clinical Trials Register international registries of ongoing studies, including the REDEFINE and TRIUMPH programmes Referral via a GP or specialist to a trial centre In the meantime, men with obesity or type 2 diabetes should be aware that NICE-approved treatments are already available and may offer meaningful clinical benefit: Semaglutide (Wegovy) is approved by NICE (TA875) for weight management in adults with a BMI 35 kg/m (or lower thresholds for certain ethnic groups) and at least one weight-related comorbidity, subject to specialist tier service criteria and duration requirements

These interrelated pathological processes include protein homeostasis dysregulation, mitochondrial dysfunction, oxidative stress, neuroinflammation, synaptic impairment, and metabolic disturbances such as iron and cholesterol dysregulation