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Preclinical studies in animal models consistently indicate that, within the tens to hundreds of nanometers range, there is a trade-off between circulation time, transvascular extravasation and tissue penetration [38,39,40]

Besides messenger RNAs, miRNAs have been reported to interact with small nuclear, ribosomal, transfer and long non-coding RNAs, although the functional significance of these interactions remains unclear

Gain-of-function mutations of SLC16A11 contribute to the pathogenesis of type 2 diabetes

The advantage of these linkers is that they not only maintain the ADCs' drug stability in blood circulation but also enable the rapid release of cytotoxins in the tumor site