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This difference was achieved without any change in food intake, suggesting the weight loss came from metabolic changes rather than appetite suppression

Research Highlights Animal Studies : Genetically obese rats treated with AOD-9604 showed significant fat loss, confirming its lipolytic effect via 3-adrenergic pathways

Second, the respective study populations were quite different, with STEP 1 including a younger, healthier population with more women (73.1% of the semaglutide arm in STEP 1 versus 27.7% in SELECT) and higher mean BMI (37.8 kg m 2 versus 33.3 kg m 2 , respectively) 14,21

But, whether or not to use them should depend on what each patient needs and what the doctor says