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In practice, even well-designed studies can encounter issues, not because data are absent, but because they are fragmented or disconnected from the broader study context

Despite this, its high efficacy and favorable safety profile make it a top choice among fitness enthusiasts and individuals on a weight loss journey who are seeking to improve muscle mass, body composition, and overall well-being through selectively stimulating growth hormone release

Vidal, 2011

A 2025 Endocrine Society presentation put the figure near 40 percent for semaglutide, and a 2024 Circulation clinical primer reported a similar range across the drug class