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Furthermore, IFN-induced arginine depletion, subsequent GCN2 expression, and autophagy contribute to the transformation of bovine epithelial mammary cells and tumorigenesis [94]

These results supported the hypothesis that ACTL6A impacts GSH de novo synthesis mainly by regulating GCLC expression

However, despite these limitations, the results collectively emphasize the crucial role of Nrf2-mediated oxidative stress in regulating the pathogenesis of RA, providing new insights for the clinical treatment of this condition (Fig

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