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and skin alterations consistent with hepatocutaneous syndrome.7, 24 No clear breed predisposition is observed with canine liver cancer, although Poodles, Fox Terriers, Miniature Schnauzers, Labrador Retrievers, and male dogs are overrepresented in some reports of hepatocellular carcinoma.1, 12, 19, 25, 26 Labrador Retrievers and female dogs are overrepresented in reports of bile duct carcinoma.1, 26, 27, 28 Whether male and female cats are equally at risk for bile duct carcinomas is unsettled,28, 29 but male cats appear to be at greater risk for bile duct adenomas.30, 31 Neuroendocrine tumors are generally observed in younger animals.1, 32 Diagnosis Definitive diagnosis of liver cancer can be made only by liver biopsy
